Two of my favorite places would be the Peculier Pub in the Village and Heartland Brewery.
The Peculier Pub is obsessed with beer. They've over 300 international brews. Fifteen are on tap, including the Belgian Strong Ale called Deilirium Tremens. Peculier's been around for 30 years so, they've the beer business down to a science.
Heartland Brewery is great because there are so many of them. Midtown, Theatre District and even on the South Street Seaport. I'd recommend the South Street Seaport for great views and access to the Bodies Exhibit. For late night happy hour, the Union Square location is clutch!
Happy Spring, Beer Lovers!